Therefore, researchers have turned to using clinically relevant allergens, such as HDM. However, OVA is not a clinically relevant allergen and the in-vivo sensitization process with aluminum adjuvants is drastically different from humans sensitized by allergens only. Traditionally, ovalbumin (OVA) has been used to induce both acute and chronic experimental allergic asthma in mice. The development of novel therapeutics for asthma requires appropriate animal models that can reliably reproduce many aspects of human asthma: airway hyperresponsiveness (AHR), reversible airway obstruction, early and late asthmatic responses, airway remodeling, and eosinophilia.
![hdm 4 model hdm 4 model](https://i.ytimg.com/vi/6vW992OwAzQ/maxresdefault.jpg)
Of these allergens, house dust mite (HDM) is the most important indoor allergen for humans (1, 2). Sirius Red/Fast Green Collagen StainingĪllergy Models - House Dust Mite-Induced AsthmaĪsthma is caused by exposure to allergens such as dust mites, pet dander, pollen, or mold, and is characterized by airflow obstruction and bronchospasm.Dextran Sulfate Sodium (DSS) for Colitis.MTT Cell Proliferation and Viability Assay.CAIA - Collagen Antibody Induced Arthritis.